98645-43-3Relevant articles and documents
An efficient method for the preparation of 4-alkoxy-substituted thieno[2,3-b]pyridines
Saito, Keiji,Naito, Satoru,Shinozuka, Tsuyoshi
, p. 1491 - 1501 (2014/07/07)
An efficient method for the preparation of 4-alkoxy-substituted thieno[2,3-b]pyridines is described. The key intermediates, 4-alkoxy-2-chloro-3- cyanopyridines, were synthesized from a variety of alcohols by nucleophilic substitution with 3-cyano-2,4-dich
Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain
Sasikumar,Qiang, Li,Burnett, Duane A.,Greenlee, William J.,Li, Cheng,Heimark, Larry,Pramanik, Birendra,Grilli, Mariagrazia,Bertorelli, Rosalia,Lozza, Gianluca,Reggiani, Angelo
scheme or table, p. 3199 - 3203 (2010/03/03)
Introduction of small unsaturated alkylamino groups at the 4-position of the A-ring of the tricyclic framework (triazafluorenone) afforded extremely potent and selective mGluR1 antagonists with desirable properties. Compounds 11q and 11s are active in the
THIENOPYRIDINE DERIVATIVES
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Page/Page column 142, (2010/11/26)
The present invention provides a compound promoting osteogenesis. The present invention provides a compound having the following general formula (I) wherein R 1 is H or alkyl, R 2 is R a S-, R a O-, R a NH-, R a (R b )N- or cyclic amino, and R a and R b are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.
FUSED TRICYCLIC MGLUR1 ANTAGONISTS AS THERAPEUTIC AGENTS
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Page/Page column 45; 55-56, (2010/11/26)
In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1-R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, part
Synthesis of 1,4-dihydro-2-methyl-4-oxo-nicotinic acid: Ochiai's route failed
Ferlin, Maria Grazia,Di Marco, Valerio B.,Dean, Annalisa
, p. 6222 - 6227 (2007/10/03)
The synthesis of 1,4-dihydro-2-methyl- and 1,4-dihydro-1,2-dimethyl-4-oxo-nicotinic acids was accomplished following a route other than Ochiai's procedure, which yielded the isomer 1,6-dihydro-2-methyl-6-oxo-nicotinic acid ethyl ester, and not the 4-oxo-derivative, as reported. Analytical data confirmed the identity of the two isomer oxo-nicotinic acids. UV-vis and potentiometric preliminary data showed that Al(III) does not form complexes with 1,6-dihydro-2-methyl-6-oxo-nicotinic acid ethyl ester in solution, as expected, but with 1,4-dihydro-2-methyl-4-oxo-nicotinic acid.
Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists
Zheng, Guo Zhu,Bhatia, Pramila,Daanen, Jerome,Kolasa, Teodozyj,Patel, Meena,Latshaw, Steven,El Kouhen, Odile F.,Chang, Renjie,Uchic, Marie E.,Miller, Loan,Nakane, Masaki,Lehto, Sonya G.,Honore, Marie P.,Moreland, Robert B.,Brioni, Jorge D.,Stewart, Andrew O.
, p. 7374 - 7388 (2007/10/03)
SAR (structure-activity relationship) studies of triazafluorenone derivatives as potent mGluR1 antagonists are described. The triazafluorenone derivatives are non-amino acid derivatives and noncompetitive mGluR1 antagonists that bind at a putative alloste
Structure-driven HtL: Design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity
Stocks, Michael J.,Barber, Simon,Ford, Rhonan,Leroux, Frederic,St-Gallay, Steve,Teague, Simon,Xue, Yafeng
, p. 3459 - 3462 (2007/10/03)
The design and synthesis of a new series of c-Jun N-terminal kinase inhibitors are reported. The novel series of substituted amino indazoles were designed based on a combination of hits from high-throughput screening and X-ray crystal structure informatio
