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CAS

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MacaMide IMpurity 10 is a chemical impurity found in maca, a root vegetable native to the Andes mountains in South America. Structurally related to the bioactive compound maca, it is often present in maca extracts and supplements as a byproduct of the manufacturing process. Although not well-studied, MacaMide IMpurity 10 is important to consider for its potential impact on the quality and safety of maca products. Further research is needed to determine its specific properties and potential risks.
Usage:
MacaMide IMpurity 10 is not well-documented for specific applications due to its limited study. However, as a byproduct of maca, it may have potential uses in the following industries:
Used in Pharmaceutical Industry:
MacaMide IMpurity 10 could be used as a research compound for further studies to understand its properties and potential effects on human health. This could contribute to the development of maca-based pharmaceutical products with improved quality and safety.
Used in Nutraceutical Industry:
As a byproduct of maca, MacaMide IMpurity 10 may be used in the development of nutraceutical products, provided its potential effects and safety are well-understood. It could contribute to the overall nutritional profile of maca-based supplements.
Used in Research and Development:
MacaMide IMpurity 10 can be used as a subject for research and development in the field of chemistry and biology. Understanding its properties and potential interactions with other compounds could lead to new insights and applications.

883715-22-8

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883715-22-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 883715-22-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,3,7,1 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 883715-22:
(8*8)+(7*8)+(6*3)+(5*7)+(4*1)+(3*5)+(2*2)+(1*2)=198
198 % 10 = 8
So 883715-22-8 is a valid CAS Registry Number.

883715-22-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (9Z,12Z)-N-(3-methoxybenzyl)octadeca-9,12-dienamide

1.2 Other means of identification

Product number -
Other names N-(3-methoxybenzyl)-(9Z,12Z)-octadecadienamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:883715-22-8 SDS

883715-22-8Downstream Products

883715-22-8Relevant articles and documents

N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain

Singh, Nalin,Barnych, Bogdan,Morisseau, Christophe,Wagner, Karen M.,Wan, Debin,Takeshita, Ashley,Pham, Hoang,Xu, Ting,Dandekar, Abhaya,Liu, Jun-Yan,Hammock, Bruce D.

, p. 3689 - 3697 (2021/01/09)

Lepidium meyenii (maca), a plant indigenous to the Peruvian Andes, recently has been utilized globally for claimed health or recreational benefits. The search for natural products that inhibit soluble epoxide hydrolase (sEH), with therapeutically relevant potencies and concentrations, led to the present study on bioactive amide secondary metabolites found in L. meyenii, the macamides. Based on known and suspected macamides, 19 possible macamides were synthesized and characterized. The majority of these amides displayed excellent inhibitory potency (IC50 ≈ 20-300 nM) toward the recombinant mouse, rat, and human sEH. Quantitative analysis of commercial maca products revealed that certain products contain known macamides (1-5, 8-12) at therapeutically relevant total concentrations (≥3.29 mg/g of root), while the inhibitory potency of L. meyenii extracts directly correlates with the sum of concentration/IC50 ratios of macamides present. Considering both its in vitro efficacy and high abundance in commercial products, N-benzyl-linoleamide (4) was identified as a particularly relevant macamide that can be utilized for in vivo studies. Following oral administration in the rat, compound 4 not only displayed acceptable pharmacokinetic characteristics but effectively reduced lipopolysaccharide-induced inflammatory pain. Inhibition of sEH by macamides provides a plausible biological mechanism of action to account for several beneficial effects previously observed with L. meyenii treatments.

Maca amide synthesis method and use thereof

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Paragraph 0074-0076, (2017/09/12)

The invention relates to a synthetic method of MACAmide. The method includes following steps: with a fatty acid and benzylamine or m-methoxybenzylamine as reaction raw materials, mixing the raw materials in a dichloromethane solution in which HOAt, EDC.HCl and DIPEA are dissolved; performing a reaction with stirring; washing a reaction product with water; and drying a substance being undissolved in water to obtain the MACAmide. The method is simple in processes and the raw materials are easy to obtain. Operation conditions of the method are easy to control. The reaction product can reach a purity of 95% without purification. The invention provides basis for industrialized synthesis of the MACAmide. In addition, the MACAmide has effects of enhancing male reproductive ability and treating male sexual dysfunction. The invention provides market prospects to application of the MACAmide.

Macamides and their synthetic analogs: Evaluation of in vitro FAAH inhibition

Wu, Hui,Kelley, Charles J.,Pino-Figueroa, Alejandro,Vu, Huyen D.,Maher, Timothy J.

, p. 5188 - 5197 (2013/09/02)

Maca (Lepidium meyenii), a traditional food crop of the Peruvian Andes is now widely touted as a dietary supplement. Among the various chemical constituents isolated from the plant are a unique series of non-polar, long-chain fatty acid N-benzylamides known as macamides. We have synthesized 11 of the 19 reported macamides and have tested each as potential inhibitors of the human enzyme, fatty acid amide hydrolase (FAAH). The five most potent macamides were FAAH inhibitors (IC50 = 10-17 μM). These amides were derivatives of oleic, linoleic and linolenic acids and benzylamine or 3-methoxybenzylamine. Of the three compounds evaluated in a pre-incubation time study, two macamides were not irreversible inhibitors of FAAH. The third, a carbamate structurally related to macamides, was shown to be an irreversible inhibitor of FAAH (IC50 = 0.153 μM).

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