881674-56-2Relevant articles and documents
Synthesis method of 5-(2-fluorophenyl)-1H-pyrrole-3-formaldehyde
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, (2021/01/20)
The invention discloses a synthetic method of 5-(2-fluorophenyl)-1H-pyrrole-3-formaldehyde, and belongs to the field of organic synthesis. The preparation method comprises the following steps: (1) reacting 2-fluoro acetophenone with a bromination reagent
Preparation method of fumaric acid Vonoprazan intermediate
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Paragraph 0061-0085, (2021/07/28)
The invention relates to a preparation method of a fumaric acid Vonoprazan intermediate. In order to solve the problems that in the reaction process, many byproducts are produced and the product is easy to degrade, in the post-treatment process, the pH va
Preparation method 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde
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Paragraph 0079-0100, (2021/10/20)
The invention provides a preparation method of 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde, which comprises the following steps of A: 2 - chlorine -5 - (2 - fluorophenyl) - 1H - pyrrole -3 - carbonitrile in a solvent. In the base and palladium
Preparation method 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde
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Paragraph 0072-0089, (2021/11/19)
The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a preparation method of 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde. The preparation method of 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - for
Preparation method of vonoprazan fumarate intermediate
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Paragraph 0056-0066, (2021/06/21)
The invention provides a preparation method of a vonoprazan fumarate intermediate, and particularly provides a preparation method of a compound shown as a formula I. The preparation method comprises the following steps: reacting o-fluorobenzonitrile with
Substituted pyrrole-4-alkylamine compounds and application thereof
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, (2018/10/19)
The invention relates to substituted pyrrole-4-alkylamine compounds and application thereof. The invention particularly provides application of compounds shown in a formula I, or optical isomers thereof, or racemates thereof, or solvates thereof, or pharm
METHOD FOR PRODUCING PYRROLE COMPOUND
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Paragraph 0139; 0140; 0141, (2018/07/29)
The present invention provides a production method of a 3-cyanopyrrole compound possibly useful as an intermediate for pharmaceutical products. A production method of compound (II) including subjecting compound (I) to a reduction reaction, in which the af
Application of 2-aryl substituted pyrrole compound in medicine for killing oncomelania hupensis
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Paragraph 0060; 0062; 0070; 0071, (2019/01/08)
The invention relates to an application of 2-aryl substituted pyrrole compound in a medicine for killing oncomelania hupensis and belongs to the technical field of prevention and treatment of bilharziasis, and particularly provides the chemical structure of the 2-aryl substituted pyrrole compound and a preparation method of same. The 2-aryl substituted pyrrole compound, being an active component,is used for preparing the snail killing agent in the forms of suspending agents, emulsions and micro-emulsions for killing the oncomelania hupensis. Immersion killing use amount of the 2-aryl substituted pyrrole compound being the active component of the snail killing agent is 0.1-10.00 mg/l, and immersion killing time is 24-72 h. The use amount of spray application is 1-10 g/m and action timeis 3-7 days. Experiment proves that the 2-aryl substituted pyrrole compound has killing activity on the oncomelania hupensis and is lower than a snail killing agent, niclosamide, in the prior art in toxicity on aquatic organisms. The compound can be processed to prepare the snail killing agents and applied in the field of prevention and treatment of bilharziasis.
Application of 2-aryl substituted pyrrole compound in medicine for killing biomphalarid snails
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Paragraph 0068; 0070; 0078; 0079, (2019/01/08)
The invention relates to an application of 2-aryl substituted pyrrole compound in a medicine for killing biomphalarid snails and belongs to the technical field of prevention and treatment of bilharziasis, and particularly provides the chemical structure of the 2-aryl substituted pyrrole compound and a preparation method of same. The 2-aryl substituted pyrrole compound, being an active component, is used for preparing the snail killing agent in the forms of suspending agents, emulsions and micro-emulsions for killing the biomphalarid snail. Immersion killing use amount of the 2-aryl substitutedpyrrole compound being the active component of the snail killing agent is 0.5-10.00 mg/l, and immersion killing time is 24-72 h. Experiment proves that the 2-aryl substituted pyrrole compound has killing activity on the biomphalarid snails and is lower than a snail killing agent, niclosamide, in the prior art in toxicity on aquatic organisms. The compound can be processed to prepare the snail killing agents and applied in the field of prevention and treatment of bilharziasis.
