774549-97-2

• 

• Basic information

  1. Product Name: KM 11060
  2. Synonyms: 7-CHLORO-4-(4-(4-CHLOROPHENYLSULFONYL)PIPERAZIN-1-YL)QUINOLINE;7-CHLORO-4-[4-[4-CHLOROPHENYL)SULFONYL]-1-PIPERAZINYL]QUINOLINE;KM 11060;CFTR-F508del Corrector, KM11060
  3. CAS NO:774549-97-2
  4. Molecular Formula: C₁₉H₁₇Cl₂N₃O₂S
  5. Molecular Weight: 422.334
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 774549-97-2.mol

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 607.3°C at 760 mmHg
  3. Flash Point: 321.1°C
  4. Appearance: /
  5. Density: 1.449g/cm³
  6. Vapor Pressure: 1.07E-14mmHg at 25°C
  7. Refractive Index: 1.675
  8. Storage Temp.: Store at RT
  9. Solubility: N/A
  10. CAS DataBase Reference: KM 11060(CAS DataBase Reference)
  11. NIST Chemistry Reference: KM 11060(774549-97-2)
  12. EPA Substance Registry System: KM 11060(774549-97-2)

• Safety Data

  1. Hazard Codes: T
  2. Statements: 25
  3. Safety Statements: 45
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 774549-97-2(Hazardous Substances Data)

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774549-97-2 Usage

Uses

Used in Pharmaceutical Industry:
KM 11060 is used as a therapeutic agent for the treatment of cystic fibrosis. It targets the F508del CFTR trafficking defect, which is a primary cause of the disease. By correcting this defect, KM 11060 has the potential to alleviate the symptoms and improve the quality of life for patients with cystic fibrosis.

Biological Activity

Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.

Check Digit Verification of cas no

The CAS Registry Mumber 774549-97-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,4,5,4 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 774549-97:
(8*7)+(7*7)+(6*4)+(5*5)+(4*4)+(3*9)+(2*9)+(1*7)=222
222 % 10 = 2
So 774549-97-2 is a valid CAS Registry Number.

InChI:InChI=1/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2

774549-97-2Upstream product

• 86-98-6 4,7-dichloroquinoline 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 837-52-5 7-chloro-4-piperazinylquinoline 

774549-97-2Downstream Products

774549-97-2Relevant articles and documents

Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl)quinoline- sulfonamide as hybrid antiprotozoal agents

Salahuddin, Attar,Inam, Afreen,Van Zyl, Robyn L.,Heslop, Donovan C.,Chen, Chien-Teng,Avecilla, Fernando,Agarwal, Subhash M.,Azam, Amir

, p. 3080 - 3089 (2013/07/05)

A new series of 4-aminochloroquinoline based sulfonamides were synthesized and evaluated for antiamoebic and antimalarial activities. Out of the eleven compounds evaluated (F1-F11), two of them (F3 and F10) showed good activity against Entamoeba histolyti

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