55727-23-6Relevant articles and documents
Design and synthesis of new curcuminoid compounds and their derivatives as antioxidant agents
Abood, Rehab G.,Alsalim, Tahseen A.,Abood, Einas A.
, p. 2173 - 2183 (2021/04/22)
A series of new curcumin analogues and their derivatives were synthesized by reacting curcumin analogues with various substituted hydrazine compounds to afford new pyrazol derivatives. The preparation of ether and ester derivatives was also carried out. All synthesized compounds were characterized using FT-IR, 1HNMR, 13CNMR, and MS-ESI. The evaluations of these compounds have shown a good inhibition activity as antioxidant agents against the stable radical of diphenylpicrylhydrazyl (DPPH). Findings from this work demonstrated a high inhibition activity in compounds substituted with hydroxyl phenol groups in comparison with compounds with other groups.
Preparation of 3- (1,3-dithiane-2-ylidene)pentan-2,4-dione and method for separating palladium from platinum through extraction by using same
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Paragraph 0006, (2019/05/08)
The invention discloses preparation of 3- (1,3-dithiane-2-ylidene)pentan-2,4-dione and a method for separating palladium from platinum through extraction by using the same, and belongs to preparationand use of ketene dithioacetal compounds. The compound adopts a molecular formula of C9H12O2S2, Mr 216. The preparation comprises the following steps: dissolving a certain amount of anhydrous potassium carbonate in DMF, adding a proper amount of acetylacetone, reacting for 50min, dropwise adding an equimolar amount of carbon disulfide, reacting for a certain period of time, then dropwise adding anequimolar amount of 1,3-dibromopropane, reacting for 4 hours, then washing by using water, recrystallizing and drying. The extraction comprises the following steps: preparing an aqueous phase, and keeping the pH of a palladium-platinum mixed solution at 2; preparing an organic phase, and mixing the phases according to a phase ratio of 1:1, transferring palladium from the aqueous phase to the organic phase and reversely extracting the palladium by using thiourea with the concentration of 1.0mol/L. The 3- (1,3-dithiane-2-ylidene)pentan-2,4-dione has high-efficiency palladium extracting performance in a hydrochloric acid medium, has a high palladium and platinum separating degree and has the palladium extracting rate as high as 97.58%.
α-alkenoyl ketene S,S-acetal-based multicomponent reaction: An efficient approach for the selective construction of polyfunctionalized cyclohexanones
Ma, Yuhui,Wang, Mang,Li, Dan,Bekturhun, Bahargul,Liu, Jun,Liu, Qun
supporting information; experimental part, p. 3116 - 3121 (2009/08/15)
A versatile multicomponent reaction based on the new four-carbon synthons α-alkenoyl ketene S,S- acetals 1 has been developed. This three-component reaction of readily available α-alkenoyl ketene S,S- acetals 1 with aldehydes 2 and active methylene compou
Synthesis of functionalized allylic sulfoxides and their use in the construction of 2,3,4-trisubstituted furans via a [3 + 2] annulation
Fu, Zhenqian,Wang, Mang,Ma, Yuhui,Liu, Qun,Liu, Jun
, p. 7625 - 7630 (2008/12/22)
(Chemical Equation Presented) A route to 2,3,4-trisubstituted furan derivatives based on a [3 + 2] annulation of functionalized allylic sulfoxides and aldehydes is described. In this strategy, the precursors of allylic sulfoxides 4, allylic sulfides 3, were synthesized via a thiomethylation reaction of an α-EWG ketene-S,S-acetal 1 (EWG: electron-withdrawing group), formaldehyde, and a thiol 2 in high to excellent yields. Allylic sulfoxides 4 were prepared by a highly regioselective oxidation of 3, using m-chloroperoxybenzoic acid as oxidant. Thus, starting from these readily available sulfoxides 4, 2-alkylthio-3,4-disubstituted furans 6 were efficiently constructed via the [3 + 2] annulation reaction of 4 with aldehydes 5 under mild conditions. Further replacement of the 2-alkylthio group of 6 with amines led to the formation of 2-amino-3,4-disubstituted furan derivatives 7.
A clean, facile and practical synthesis of α-oxoketene S,S-acetals in water
Ouyang, Yan,Dong, Dewen,Yu, Haifeng,Liang, Yongjiu,Liu, Qun
, p. 206 - 210 (2007/10/03)
A clean, facile and practical synthesis of α-oxoketene S,S-acetals in water has been developed. Catalyzed by tetrabutylammonium bromide (TBAB) at room temperature in water, a range of β-dicarbonyl compounds have been converted to the corresponding α-oxoke
Vilsmeier-Haack reaction of α-oxo ketene dithioacetals to α-chlorovinyl/ethynyl ketene dithioacetals
Dong, Dewen,Liu, Yingchun,Zhao, Yulong,Qi, Yimei,Wang, Zhuo,Liu, Qun
, p. 85 - 91 (2007/10/03)
A range of α-oxo ketene dithioacetals 1 reacted with Vilsmeier reagent (POCl3/DMF) to afford a-chlorovinyl ketene dithioacetals 2, With the treatment of NaOH in ethanol or methanol, the compounds 2 were transformed into the corresponding α-ethynyl ketene dithioacetals 3 in moderate to high yields.
α,α-diacetyl cyclic ketene dithioacetals: Odorless and efficient dithiol equivalents in thioacetalization reactions
Yu, Haifeng,Liu, Qun,Yin, Yanbing,Fang, Qunxin,Zhang, Jingping,Dong, Dewen
, p. 999 - 1002 (2007/10/03)
Two novel, non-thiolic, odorless dithiol equivalents, α,α- diacetyl cyclic ketene dithioacetals 2a and 2b, had been developed. A range of carbonyl compounds 3 were converted into corresponding dithioacetals, dithianes 4 and dithiolanes 5, in high yields (up to 99%) in the presence of 2a or 2b. Moreover, 2a and 2b show high chemoselectivity between aldehyde and ketone in thioacetalization.
NOVEL COMPOUNDS
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Page 39, (2010/02/07)
The invention relates to thienopyridazinones of formula (I): wherein: R1 is C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl which is optionally substituted by C1-6 alkyl, each of the above being optionall
The First Nonthiolic, Odorless 1,3-Propanedithiol Equivalent and Its Application in Thioacetalization
Liu, Qun,Che, Guangbo,Yu, Haifeng,Liu, Yingchun,Zhang, Jingping,Zhang, Qian,Dong, Dewen
, p. 9148 - 9150 (2007/10/03)
2-[2-Chloro-1-(1-chlorovinyl)allylidene]-1,3-dithiane 1 was synthesized by the chlorination of 3-(1,3)-dithianylidenepentane-2,4-dione 2 using the Vilsmeier-Haack reagent in 99% yield. As a novel nonthiolic, odorless 1,3-propane-dithiol equivalent, 1 was investigated in the thioacetalization reaction. Various types of aldehydes and ketones 3 were converted to the corresponding dithianes 4 in the presence of 1 in high yields (79-97%). Moreover, 1 exhibited obvious chemoselectivity between aldehyde and ketone in this thioacetalization reaction. A mechanism for this thioacetalization reaction is proposed.
Routes to building blocks for heterocyclic synthesis by reduction of ketene dithioacetals
Mellor, John M.,Schofield, Stephen R.,Korn, Stewart R.
, p. 17151 - 17162 (2007/10/03)
Two general methods have been developed permitting the effective reduction of ketene dithioacetals to give substituted dithianes. Reduction with magnesium in methanol is less reliable than reduction with zinc in acetic acid. The greater inconsistency of magnesium in methanol has been investigated by a cyclic voltammetric study of the substrates. The utility of the dithianes has been successfully illustrated by cyclisations to afford, after deprotection, a variety of heterocyclic aldehydes.
