54556-98-8 Usage
Uses
Used in Pharmaceutical Industry:
Propiverine hydrochloride is used as an anticholinergic agent for the treatment of urinary incontinence. It helps to reduce the frequency of urination and improve bladder control by exerting neurotropic and musculotropic effects on the urinary bladder and smooth muscles.
Used in Urological Applications:
Propiverine hydrochloride is used as a spasmolytic and analgesic agent for managing pollakiuria (frequent urination) and aconuresis (inability to hold urine for a socially acceptable length of time). Its anticholinergic properties help to inhibit involuntary bladder contractions, providing relief from these urological conditions.
Brand Names:
Mictonorm and Mictonetten are the brand names under which Propiverine hydrochloride is marketed.
Originator
Apogepha (Germany)
Biochem/physiol Actions
Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.
Clinical Use
Treatment of urinary frequency, urgency and
incontinence
Neurogenic bladder instability
Drug interactions
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic
side effects with disopyramide.
Metabolism
Propiverine is extensively metabolised by intestinal and
hepatic enzymes. Four metabolites were identified in
urine; two of them are pharmacologically active and may
contribute to the therapeutic efficacy.
Propiverine and its metabolites are excreted in the urine,
bile and faeces.
Check Digit Verification of cas no
The CAS Registry Mumber 54556-98-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,5,5 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 54556-98:
(7*5)+(6*4)+(5*5)+(4*5)+(3*6)+(2*9)+(1*8)=148
148 % 10 = 8
So 54556-98-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H31NO2.ClH/c1-3-4-17-24(20-11-7-5-8-12-20,21-13-9-6-10-14-21)23(26)27-22-15-18-25(2)19-16-22;/h5-14,22H,3-4,15-19H2,1-2H3;1H
54556-98-8Relevant articles and documents
Preparation method of propiverine hydrochloride
-
Paragraph 0017-0018, (2018/03/25)
The invention relates to a preparation method of propiverine hydrochloride; a compound represented by the formula I and 1-methyl-4-piperidinol are subjected to transesterification, and then are subjected to hydrochlorination to generate the product propiverine hydrochloride. The used raw materials and the reaction route are all simple and easy to obtain. More importantly, through scale-up experiment of the route, the yield and purity of the product obtained by the preparation method are found to have little difference from those of a product obtained in laboratories, and the preparation methodis suitable for industrialized popularization.
SYNTHESIS OF PROPIVERINE HYDROCHLORIDE
-
Page/Page column 6-7, (2011/10/10)
The present invention provides a two step esterification process for the synthesis of Propiverine hydrochloride. In the synthetic scheme disclosed herein benzillic acid 1 is directly converted to di-propyl ester ether 7 from the known standard method. The intermediate thus obtained is reacted with N-Methyl 4-hydroxy piperidine in the presence of sodium t-butoxide at room temperature to get Propiverine base 5. This is then finally converted to Propiverine hydrochloride. The process of synthesis provides Propiverine hydrochloride in a very pure form (>99%) with a very good yield. The compound is very useful in treating urinary incontinence.
