537-65-5Relevant articles and documents
Cardanol Schiff base antioxidant as well as preparation method and application thereof
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Paragraph 0076-0078, (2020/06/20)
The invention discloses a cardanol Schiff base antioxidant, which comprises a compound having a structure represented by the formula shown in the specification, wherein R is selected from any one of the structures shown in the specification, R1 is independently selected from H or the structure represented by the structure shown in the specification. The invention also discloses a method for preparing the cardanol Schiff base antioxidant. The cardanol Schiff base antioxidant disclosed by the invention has excellent thermal stability and good oxidation resistance and corrosion resistance, the preparation process is simple and feasible, the reaction conditions are mild and rapid, and the aftertreatment is simple and convenient. The cardanol Schiff base antioxidant disclosed by the invention is suitable for being widely applied to the fields of lubricating oil, lubricating grease and the like.
DERIVATIVES OF PPD USEFUL FOR COLORING HAIR AND SKIN
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Page/Page column 30; 31, (2019/06/09)
The is provided a compound of formula I or II or physiologically acceptable salts or solvates, or oxidised derivatives thereof: where R1 to R3, R13 and R14 are as defined herein. Also disclosed herein are methods of dyeing hair or (temporarily) tattooing the skin using the compounds of formula I or II (or physiologically acceptable salts or solvates, or oxidised derivatives thereof) in a suitable composition.
Facile synthesis of oligo anilines as permanent hair dyes: How chemical modifications impart colour and avoid toxicity
Venkatesan, Gopalakrishnan,Dancik, Yuri,Sinha, Arup,Bigliardi, Mei,Srinivas, Ramasamy,Dawson, Thomas,Valiyaveettil, Suresh,Bigliardi, Paul,Pastorin, Giorgia
, p. 16188 - 16199 (2019/11/03)
Many dyes for long-lasting hair coloring contain aromatic amines that undergo oxidative polymerizations, resulting in allergic contact dermatitis, with the potential to develop serious toxic effects. Among these amines, para-phenylenediamine (PPD) is a small molecule form of aniline commonly used in beauty products despite being a known allergen to humans. Hence, in this study we designed and synthesized safer PPD analogues through the synthesis of oligomeric PPD and the introduction of bulky side chains on PPD to overcome the PPD dye's toxicity. We hypothesized that (a) an increase in the molecular size of PPD by addition of the PPD monomer unit on free amines and (b) strategic functionalizations at the ortho position of PPD with strong electron-donating bulky groups are able to maintain the hair coloring properties, and increase the resistance to binding to skin proteins and therefore decrease the chance of skin sensitization. 13 oligomers were synthesized, with the aim to produce safer hair dyes while minimising eventual toxicity to humans. In particular, oligomers with bulky sidechains, PPD 6 (13), PPD 7 (14) and PPD 8 (15), displayed weak-to-moderate (27.1%, 24.1% and 34.0%) sensitization potential. The results confirmed the importance of having bulky and strong electron donating O-alkyl substituents in order to decrease the reactivity of PPD analogues towards skin proteins, thus preventing the interaction with immune cells and providing safer hair dyes.
Synthesis method of 4,4'-diamino diphenylamine
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Paragraph 0030; 0031; 0033; 0036, (2018/07/06)
The invention discloses a synthesis method of 4,4'-diamino diphenylamine. The synthesis method comprises the following operation steps that phenylenediamine and nitrophenylcarbimide are used as reactants; under certain reaction conditions, one amidogen on a benzene ring substitutes chlorine on the nitrophenylcarbimide under the effect of alkali to obtain a preliminary product of 4-nitro-4'-aminodiphenylamine; then, nitryl of 4-nitro-4'-aminodiphenylamine is subjected to hydrogenation reduction under the effect of catalysts to obtain a final product of 4,4'-diamino diphenylamine. When the scheme is adopted, the purchasing and the transportation of raw materials are very convenient; the product yield is high; the cost is low; the operation is simple; the environment pollution is little, so that the synthesis method has good industrial development prospects.
Design, synthesis and antitumor activity of novel cis-furoquinoline derivatives
Li, Jie,Pei, Shuchen,Zhu, Yingxi,Wu, Jianbo,Chen, Yin,Zhang, Weiyu,Wu, Yong
experimental part, p. 379 - 388 (2012/07/03)
A series of novel cis-furoquinoline derivatives was synthesized and tested for their antitumor activities in vitro against HepG2 cells, Lu-04 cells and Leu02 cells to evaluate structure-activity relationships. Assay-based antiproliferative activity study revealed that several compounds had significant effects on cytotoxicity, among which compounds 2f, 2l, 2q were found to be the most active compounds. Above all, compounds 2f, 2l, 2q would be potential anticancer agents which deserved further research.
Process for dyeing keratinous fibers with aminoindoles and oxidation dye precursors at basic Ph's and dyeing agents
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, (2008/06/13)
The invention relates to a process for dyeing keratinous fibres, which consists in applying to these fibres a composition containing, in a suitable medium for dyeing, at least one coupler of formula: STR1 where R1 denotes hydrogen or alkyl, R2 and R3 denote hydrogen, alkyl, COOR' where R' is alkyl or hydrogen, at least one of the groups R2 and R3 denoting hydrogen, R4 denotes hydrogen, alkyl, hydroxyalkyl, polyhydroxyalkyl or aminoalkyl, Z1 and Z2 denote hydrogen, alkyl, hydroxyl, halogen, alkoxy, at least one of the groups Z1 and Z2 is other than hydrogen at least one oxidation dye precursor, at least one oxidizing agent, the pH of the composition applied to the fibres being higher than 7.
Methods for dyeing keratinous fibers with compositions which contain aminoindole couplers, oxidation dye precursors, and oxidizing agents at acid pHs
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, (2008/06/13)
A method for dyeing keratin fibers, wherein a composition is applied to said fibers which contains, in a suitable dyeing medium, at least one coupler having formula (I) STR1 wherein R1 is hydrogen or alkyl; R2 and R3 are hydrogen, alkyl, COOR', where R' is alkyl or hydrogen; R4 is hydrogen, hydroxyalkyl, alkyl, polyhydroxyalkyl or acetyl or aminoalkyl wherein the amine may be mono- or disubstituted by alkyl; Z1 and Z2 are hydrogen, alkyl, hydroxy, halogen, alkoxy or a salt thereof; at least one precursor of an oxidation hair dye; and at least one oxidizing agent, the pH of the composition applied to the fibers being less than 7.
Process for preparing substituted aromatic azo compounds
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, (2008/06/13)
A process for preparing substituted aromatic azo compounds is provided which comprises contacting a nucleophilic compound and an azo containing compound in the presence of a suitable solvent system, and reacting the nucleophilic compound and the azo containing compound in the presence of a suitable base and a controlled amount of protic material at a temperature of about 10° C. to about 150° C. in a confined reaction zone wherein the molar ratio of protic material to base is 0:1 to about 5:1.
Basic azo dyestuffs of the 3-cyano-2,4,6-triamino pyridine series
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, (2008/06/13)
The new basic azo dyestuffs of the formula STR1 wherein the symbols have the meaning given in the description, are suitable for dyeing synthetic and naturally occurring substrates which can be dyed with basic dyestuffs.
Reaction product of a rosin acid and an antidegradant
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, (2008/06/13)
There is disclosed a reaction product of a rosin acid and a polyfunctional compound having at least one functional group capable of reacting with a carboxylic acid functionality and another functional group having antidegradant properties. The reaction products of this invention can be used as antidegradants in polymeric compositions and lubricating oil compositions.
