52182-15-7Relevant articles and documents
NOVEL COMPOUNDS AS ANTI-TUBERCULAR AGENTS
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, (2015/12/17)
The present invention relates to novel compounds of formula (1): The present invention also discloses compounds of formula (1) along with other pharmaceutical acceptable excipients and use of the compounds as anti-tubercular agents.
Synthesis of 1,2,4-trioxepanes and 1,2,4-trioxanes via Hmediated reaction of tertiary carbinols
Ravi, Makthala,Anand, Devireddy,Maurya, Ranjani,Chauhan, Parul,Naikade, Niraj K.,Shukla, Sanjeev K.,Yadav, Prem P.
, p. 173 - 176 (2013/02/26)
A facile and efficient method for the synthesis of 1,2,4-trioxepanes and 1,2,4-trioxanes from different carbinols having cyclopropyl and phenyl substituents has been developed. The corresponding hydroxyhydroperoxides were synthesized from 30% Hmediated reaction of carbinols in acidic conditions. This method provided access to novel 6,6-diaryl-substituted 1,2,4-trioxanes derived from benzilic acid. Georg Thieme Verlag Stuttgart · New York.
One-pot synthesis of cyclophane-type macrocycles using manganese(iii)- mediated oxidative radical cyclization
Ito, Yosuke,Tomiyasu, Yuichi,Kawanabe, Takahiro,Uemura, Keisuke,Ushimizu, Yuu,Nishino, Hiroshi
supporting information; scheme or table, p. 1491 - 1507 (2011/04/23)
Cyclophane-type macrocyclic compounds from 21 to 56 members having two fused dihydrofuran rings were synthesized by the manganese(iii)-mediated oxidation of terminal dienes with bis(3-oxobutanoate)s containing aromatics. The reaction detail, characterization and reaction pathways are described. The Royal Society of Chemistry 2011.
Rhodium-catalyzed diarylation of oxalates using arylboron compounds
Miyamura, Sawako,Satoh, Tetsuya,Miura, Masahiro
, p. 2255 - 2257 (2007/10/03)
Dialkyl oxalates undergo selective diarylation on one of their carbonyl carbons upon treatment with arylboron reagents in the presence of a rhodium catalyst to give the corresponding α-hydroxydiarylacetates. Under similar conditions, the arylation of benzoylformate and benzil also proceeds efficiently.
Anionic four-electron donor-based palladacycles as catalysts for addition reactions of arylboronic acids with α,β-unsaturated ketones, aldehydes, and α-ketoesters
He, Ping,Lu, Yong,Dong, Cheng-Guo,Hu, Qiao-Sheng
, p. 343 - 346 (2007/10/03)
(Chemical Equation Presented) Anionic four-electron donor-based palladacycle-catalyzed 1,4-additions of arylboronic acids with α,β-unsaturated ketones and 1,2-additions of arylboronic acids with aldehydes and α-ketoesters are described. Our study demonstrated that palladacycles were highly efficient, practical catalysts for these addition reactions. The work described here not only opened a new paradigm for the application of palladacycles, but may also pave the road for other metalacycles as practically useful catalysts for such addition reactions including asymmetric ones.
Phosphinite- and phosphite-based type I palladacycles as highly active catalysts for addition reactions of arylboronic acids with aldehydes, α,β-unsaturated ketones, α-ketoesters, and aldimines
He, Ping,Lu, Yong,Hu, Qiao-Sheng
, p. 5283 - 5288 (2008/02/09)
Phosphinite- and phosphite-based type I palladacycle-catalyzed additions of arylboronic acids with aldehydes, α,β-unsaturated ketones, α-ketoesters, and aldimines are described. Our study showed that readily available phosphinite- and phosphite-based type I palladacycles could possess higher catalytic activity than phosphine-based palladacycles and were highly active, practical catalysts. Our study may pave the road for development of optically active phosphinite- and phosphite-based palladacycles for asymmetric catalysis.
Rhodium-catalyzed addition of arylstannanes to carbon-heteroatom double bond
Oi, Shuichi,Moro, Mitsutoshi,Fukuhara, Hiroe,Kawanishi, Takanori,Inoue, Yoshio
, p. 4351 - 4361 (2007/10/03)
The addition of arylstannanes to the carbon-heteroatom double bond in the presence of a catalytic amount of a cationic rhodium complex ([Rh(cod)(MeCN)2]BF4) was examined. The reactions of aldehydes, α-dicarbonyl compounds, and N-substituted aldimines with the arylstannanes gave corresponding alcohols, α-hydroxy carbonyl compounds, and amines, respectively. An arylrhodium complex generated by the transmetalation with the arylstannane was probably the active catalytic species.
Reactions of Grignard reagents with bis- or mono-phosphonium ions in Situ generated from Bu3P and dicarboxylic acid dichlorides or ω-ethoxycarbonyl alkanoyl chlorides as a novel method to obtain diketones and ketoesters
Maeda,Hino,Yamauchi,Ohmori
, p. 1196 - 1199 (2007/10/03)
Reactions of Grignard reagents with bis-phosphonium or mono-phosphonium ions in situ generated from Bu3P and ClCO(CH2)(n)COCl (5) or ClCO(CH2)(n)CO2Et (13) as a tool for preparation of symmetrical diketones or ketoesters were examined. Addition of Bu3P (2.0 eq) to a THF solution of 5 (n=2) at -40°C followed by addition of n-BuMgCl (2.0 eq) gave the corresponding diketone in good yield. When a mixture of Bu3P and the Grignard reagent (2.0 eq each) was added to the dichloride solution at the same temperature, a better result was obtained. The latter method not with PhMgBr but with n-BuMgCl or MeMgBr was shown to be useful for preparation of symmetrical alkanediones and keto alkanoates from various 5 (n=2 - 6) and 13 (n=2 or 3), respectively. For synthesis of α-diketones or α-ketoesters, only PhMgBr entered the reaction, although the yields were not satisfactory. Addition of a mixture of Bu3P (2.0 eq), MeMgBr (1.0 eq) and BuMgCl (1.0 eq) to a THF solution of 5 (n=4) at -40°C afforded a mixture of 2,7-undecanedione and the corresponding two symmetrical diketones, with the yield of the unsymmetrical diketone being 36%.
Biotransformation of denaverine hydrochloride (Spasmalgan) in the rat
Goeber, B.,Lisowski, Hannelore,Friese, Dagmar,Franke, P.
, p. 493 - 495 (2007/10/02)
After oral application of denaverine hydrochloride to rats (200-250 mg/kg) 12 metabolites have been detected in urine.Besides the unchanged drug, 8 metabolites were identified by MS as 2,2-diphenyl-(2-dimethylaminoethyl)acetate (3), diphenylacetic (5) and benzilic acid (6), methyl- and ethyl acetate (7,11), methylbenzilate (10),N-demethyl-1 (12) and 3,3-diphenylmorpholin-2-one (13). 6 and metabonate 13 represent the main metabolic products.Compounds 7 and 11 indicate the metabolic pathway about an alkoxybenzilic acid (4).Phenols resp. conjugates were not detected.
