433-53-4Relevant articles and documents
METHOD FOR PREPARING DIFLUOROACETIC ACID ESTERS
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Page/Page column 8, (2012/07/31)
A method for preparing difluoroacetic acid esters is described. The method can include reacting difluoroacetyl fluorine with an aliphatic or cycloaliphatic alcohol in the presence of a heterogeneous mineral base.
METHOD FOR PRODUCING FLUORINE-CONTAINING CARBOXYLIC ACID ESTER
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Page/Page column 6-7, (2010/04/24)
[Task] It is to provide a production method that the target fluorine-containing carboxylic acid ester can be obtained from a fluorine-containing ether by a one-step reaction, that a complicated step and a troublesome operation are not necessary, and that an excessive energy is not consumed. [Solving Means] A fluorine-containing carboxylic acid ester represented by the general formula R1HCFCOOR2 is produced by reacting a fluorine-containing ether represented by the general formula R1HCFCF2OR2 (R1 represents either of a fluorine atom and a C1-4 perfluoroalkyl group, and R2 represents a monovalent organic group) with water in the presence of a solid catalyst.
Preparation of compounds comprising a CHF2 or CHF group
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Page/Page column 2; 3, (2008/06/13)
Producing compounds (I) with a mono- or difluoromethyl group from compounds (II) with a mono- or difluorohalomethyl group, where halo is bromo, iodo or preferably chloro, comprises reacting (II) with zinc in the presence of an alcohol. An independent claim is also included for an azeotropic mixture of methyl difluoroacetate and methanol.
(METHYL DIFLUOROACETATE)COPPER REAGENT. REMARKABLE SOLVENT EFFECT ON THE 19F-NMR SPECTRUM, STABILITY AND REACTIVITY
Kitagawa, Osamu,Taguchi, Takeo,Kobayashi, Yoshiro
, p. 389 - 392 (2007/10/02)
The 19F-NMR spectrum, thermal stability and reactivity of (methyl difluoroacetate)copper reagent were found to differ remarkably depending on the solvent (DMSO, DMF, or HMPA) used.With allylic bromide or alkynyl halide a crucial solvent effect for the coupling reactions was observed.
ALDOL REACTION OF IODODIFLUOROACETATE-Zn AND 2,2-DIFLUOROKETENE SILYL ACETAL
Kitagawa, Osamu,Taguchi, Takeo,Kobayashi, Yoshiro
, p. 1803 - 1806 (2007/10/02)
Generation of the Reformatsky reagent of difluoroacetate from the iodide(2) and the difluoroketene silyl acetal(3), and their aldol reaction are described.High anti-selectivity with chiral aldehyde (5d, 5f) was found in the case of the ketene silyl acetal(3b). 2,2-Difluoro-2-deoxy analogs of D-ribo- and L-galactopyranosides (1a, 1b) were effectively prepared.
ADDITION OF 1,2-DIBROMO-1-CHLOROTRIFLUOROETHANE TO CHLOROTRIFLUOROETHYLENE INDUCED BY UV-RADIATION. SYNTHESIS OF PERFLUORO-1,3-BUTADIENE AND PERFLUORO-1,3,5-HEXATRIENE
Dedek, V.,Chvatal, Z.
, p. 363 - 380 (2007/10/02)
Photochemically initiated reaction of 1,2-dibromo-1-chlorotrifluoroethane (II) with chlorotrifluoroethylene (I) gave 38percent 1,4-dibromo-2,3-dichlorohexafluorobutane (III) and 19percent 1,6-dibromo-2,3,5-trichlorononafluorohexane (IV) in addition to the higher telomers.Dehalogenations of III and IV yielded perfluoro-1,3-butadiene (VI) and perfluoro-1,3,5-hexatriene (VIII) with 3-chlorononafluoro-1,5-hexadiene (VII), respectively.Photochemical reduction of butane III with 2-propanol resulted in a preferential reduction of C-Br bonds, and from 2,3-dichloro-1,1,2,3,4,4-hexafluorobutane (IX) thus formed, esters of difluoroacetic acid were prepared by dehalogenation of IX and subsequent oxidation and esterification of the product.The photochemical reduction of hexane IV gave a mixture of 79percent trichlorononafluorohexane XII and 21percent dichlorononafluorohexane XIII.The mechanism of formation of the unusual products of the title addition reaction is discussed.
13,14-Didehydro-PGA1 compounds
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, (2008/06/13)
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
2,2-Difluoro-13,14-didehydro-11-deoxy-17-phenyl-18,19,20-trinor-PGE2 compounds
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, (2008/06/13)
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
9-Deoxy-9,10-didehydro-PGD1 compounds
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, (2008/06/13)
Prostaglandin analogs with the following cyclopentane ring structure: STR1 are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins, particularly and especially as blood platelet aggregation inhibitors.
13,14-Didehydro-PG3 compounds
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, (2008/06/13)
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
