283-38-5

• 

• Basic information

  1. Product Name: 1,4-Diazobicylco[3.2.2]nonane
  2. Synonyms: (1s,5s)-1,4-diazabicyclo[3.2.2]nonane;1,4-Diazobicylco[3.2.2]nonane;1,4-Diazabicyclo[3.2.2]nonane, 95%
  3. CAS NO:283-38-5
  4. Molecular Formula: C₇H₁₄N₂
  5. Molecular Weight: 126.202
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 283-38-5.mol

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 180.0±8.0℃ (760 Torr)
  3. Flash Point: 71.9±9.4℃
  4. Appearance: Colorless to yellow/Waxy Solid
  5. Density: 1.03±0.1 g/cm3 (20 ºC 760 Torr)
  6. Refractive Index: N/A
  7. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
  8. Solubility: N/A
  9. PKA: 11.00±0.20(Predicted)
  10. CAS DataBase Reference: 1,4-Diazobicylco[3.2.2]nonane(CAS DataBase Reference)
  11. NIST Chemistry Reference: 1,4-Diazobicylco[3.2.2]nonane(283-38-5)
  12. EPA Substance Registry System: 1,4-Diazobicylco[3.2.2]nonane(283-38-5)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 283-38-5(Hazardous Substances Data)

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• Usage
• SDS
• Upstream product
• Downstream Products
• Article

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283-38-5 Usage

Uses

Used in Organic Synthesis:
1,4-Diazabicyclo[3.2.2]nonane is used as a strong, non-nucleophilic base for various organic synthesis reactions. Its ability to act as a base without being nucleophilic makes it a valuable reagent in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals.
Used in Pharmaceutical Synthesis:
DBN is used as a catalyst in the synthesis of pharmaceuticals, facilitating various chemical reactions and improving the efficiency of the synthesis process. Its strong basicity and non-nucleophilic nature make it suitable for a wide range of pharmaceutical applications.
Used in Agrochemical Synthesis:
1,4-Diazabicyclo[3.2.2]nonane is used as a catalyst in the synthesis of agrochemicals, aiding in the production of various agricultural chemicals and pesticides. Its strong basicity and non-nucleophilic properties contribute to the efficiency and effectiveness of these synthesis processes.
Used in Polymer and Plastics Production:
DBN is used in the production of polymers and plastics, where it acts as a catalyst or additive to improve the properties of the final products. Its strong basicity and non-nucleophilic nature make it a valuable component in the synthesis of various polymers and plastics.
Used in Removing Acidic Contaminants:
1,4-Diazabicyclo[3.2.2]nonane is used for removing acidic contaminants in organic solvents, ensuring the purity and quality of the solvents used in various chemical processes. Its strong basicity allows it to neutralize acidic impurities effectively.
Used in Lithium-Ion Batteries:
DBN is used as an additive in lithium-ion batteries, where it enhances the performance and stability of the batteries. Its strong basicity and non-nucleophilic properties contribute to the improved performance and longevity of lithium-ion batteries in various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 283-38-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,8 and 3 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 283-38:
(5*2)+(4*8)+(3*3)+(2*3)+(1*8)=65
65 % 10 = 5
So 283-38-5 is a valid CAS Registry Number.

283-38-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	1,4-diazabicyclo[3.2.2]nonane

1.2 Other means of identification

Product number	-
Other names	1,4-diazabicyclo-[3.2.2]nonane

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:283-38-5 SDS

283-38-5Upstream product

• 3731-38-2 3-Quinuclidinone 
• 150208-70-1 1,4-diazabicyclo[3.2.2]nonane dihydrochloride 
• 1193-65-3 3-quinuclidinone hydrochloride 
• 35423-17-7 3-quinuclidone oxime 
• 53619-11-7 1,4-diaza-bicyclo[3.2.2]nonan-3-one 

283-38-5Downstream Products

• 446018-75-3 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid 4-tert-butyl-phenyl ester 
• 298198-77-3 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid 4-trifluoro-methoxy-phenyl ester 
• 446018-40-2 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid 4-methylsulfanyl-phenyl ester 
• 298198-69-3 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid 3-trifluoromethyl-phenyl ester 
• 446018-85-5 1,4-diaza-bicycloF_3.2.21nonane-4-carboxylic acid 3-bromo-phenyl ester 
• 298198-62-6 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid 2-bromo-phenyl ester 
• 446018-49-1 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid 4-[1,2,4]triazol-1-yl-phenyl ester 

283-38-5Relevant articles and documents

Microwave-assisted beckmann rearrangement: Convenient synthesis of 1,3-diaza-bicyclo[3.2.2]nonane

Curtis, Michael P.,Bunnelle, William H.,Pagano, Thomas G.,Gopalakrishnan, Murali,Faghih, Ramin

, p. 321 - 326 (2006)

Small heterocyclic amines such as 1,3-diaza-bicyclo[3.2.2]nonane are known to be key components of biologically active molecules. A convenient synthesis of this compound utilizing a key Beckmann rearrangement of (Z)-1-aza-bicyclo[2.2. 2]octan-3-one oxime (6) with conc. H2SO4 under microwave irradiation was achieved. The desired compound (1) was obtained in 20% yield overall. Copyright Taylor & Francis LLC.

Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents

Shao, Hao,Foley, David W.,Huang, Shiliang,Abbas, Abdullahi Y.,Lam, Frankie,Gershkovich, Pavel,Bradshaw, Tracey D.,Pepper, Chris,Fischer, Peter M.,Wang, Shudong

supporting information, (2021/02/16)

Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases. Due to the conserved ATP binding site, designing selective CDK9 inhibitors has been challenging. Here we report our continued efforts in the optimization of 2,4,5-tri-substituted pyrimidine compounds as potent and selective CDK9 inhibitors. The most selective compound 30m was >100-fold selective for CDK9 over CDK1 and CDK2. These compounds showed broad anti-proliferative activities in various solid tumour cell lines and patient-derived chronic lymphocytic leukaemia (CLL) cells. Decreased phosphorylation of the carboxyl terminal domain (CTD) of RNAPII at Ser-2 and down-regulation of anti-apoptotic protein Mcl-1 were confirmed in both the ovarian cancer model A2780 and patient-derived CLL cells.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

-

Page/Page column 124; 125, (2015/06/25)

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy.

Glucosylceramide synthase inhibitors

-

Page/Page column 51, (2015/09/28)

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

-

Page/Page column 167, (2014/04/03)

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

1,4-DIAZABICYCLO[3.2.2]NONANES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

-

Page/Page column 32, (2013/03/26)

The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using

LABELLED AND UN-LABELLED METHYL-PYRROLYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE

-

Page/Page column 10, (2012/11/06)

The present invention relates to certain labelled or un-labelled pyrrolyl-oxadizolyl-diazabicyclononane derivatives and their medical use. Furthermore, the present invention relates to the use of said derivatives in their labelled form in diagnostic methods, in particular for in vivo receptor imaging (neuroimaging).

DIAZABICYCLONONYL OXADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

-

Page/Page column 14, (2011/07/07)

This invention relates to diazabicyclononyl oxadiazolyl derivatives, which are found to-be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Ar1 represents a pyrrolyl group, optionally substituted with alkyl or halo-alkyl.

NOVEL DIAZA-BICYCLONONYL-PHENYL DERIVATIVES AND THEIR MEDICAL USE

-

Page/Page column 17, (2010/06/20)

This invention relates to novel diazabicyclononyl-phenyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulator

N-OXIDES OF DIAZABICYCLONONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE

-

Page/Page column 16, (2010/08/08)

This invention relates to novel N-oxides of certain diazabicyclononyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine

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