24821-17-8

• 

• Basic information

  1. Product Name: 2-AMINO-3-NITROBENZOTRIFLUORIDE
  2. Synonyms: 2-AMINO-3-NITROBENZOTRIFLUORIDE;2-Nitro-6-(trifluoromethyl)aniline;2-Amino-3-nitrobenzotrifluoride, α, α, α-Trifluoro-6-nitro-ortho-toluidine;2-Amino-3-nitrobenzotrifluoride 99%;2-Amino-3-trifluoromethylnitrobenzene;2-Nitro-6-(trifluoroMethyl)aniline 97%
  3. CAS NO:24821-17-8
  4. Molecular Formula: C₇H₅F₃N₂O₂
  5. Molecular Weight: 206.1220096
  6. EINECS: N/A
  7. Product Categories: NULL
  8. Mol File: 24821-17-8.mol

• Chemical Properties

  1. Melting Point: 48-52 °C
  2. Boiling Point: 261.1°Cat760mmHg
  3. Flash Point: 110 °C
  4. Appearance: /
  5. Density: 1.503g/cm³
  6. Vapor Pressure: 0.012mmHg at 25°C
  7. Refractive Index: 1.525
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: 2-AMINO-3-NITROBENZOTRIFLUORIDE(CAS DataBase Reference)
  11. NIST Chemistry Reference: 2-AMINO-3-NITROBENZOTRIFLUORIDE(24821-17-8)
  12. EPA Substance Registry System: 2-AMINO-3-NITROBENZOTRIFLUORIDE(24821-17-8)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany: 3
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 24821-17-8(Hazardous Substances Data)

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• Usage
• SDS
• Upstream product
• Downstream Products
• Article

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24821-17-8 Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-3-NITROBENZOTRIFLUORIDE is used as a key intermediate for the synthesis of benzimidazoles, which are important compounds in the development of various pharmaceuticals. It is used in the reductive heterocyclization with orthoesters using indium, allowing for the creation of benzimidazoles with potential applications in drug discovery and medicinal chemistry.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-AMINO-3-NITROBENZOTRIFLUORIDE is utilized as a versatile reactant for the one-pot preparation of quinoxalines. This is achieved through reductive coupling with 1,2-diketones using indium. Quinoxalines are valuable compounds with a wide range of applications, including their use as building blocks in the synthesis of complex organic molecules and as active pharmaceutical ingredients.
Overall, 2-AMINO-3-NITROBENZOTRIFLUORIDE is a significant compound in the pharmaceutical and chemical industries due to its role in the synthesis of various important molecules and its potential for further research and development in drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 24821-17-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,8,2 and 1 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 24821-17:
(7*2)+(6*4)+(5*8)+(4*2)+(3*1)+(2*1)+(1*7)=98
98 % 10 = 8
So 24821-17-8 is a valid CAS Registry Number.

InChI:InChI=1/C7H5F3N2O2/c8-7(9,10)4-2-1-3-5(6(4)11)12(13)14/h1-3H,11H2

24821-17-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name	2-Nitro-6-(trifluoromethyl)aniline

1.2 Other means of identification

Product number	-
Other names	6-nitro-2-trifluoromethylaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24821-17-8 SDS

24821-17-8Upstream product

• 39974-35-1 2-chloro-1-nitro-3-(trifluoromethyl)benzene 
• 603-11-2 3-nitrophthalic acid 
• 98-46-4 3-trifluoromethylnitrobenzene 
• 24821-19-0 2-Nitro-6-trifluormethyl-benzamid 
• 88-17-5 2-(trifluoromethyl)benzenamine 

24821-17-8Downstream Products

• 389-61-7 5-trifluoromethyl-2,3-diphenylquinoxaline 
• 7641-27-2 2-phenyl-4-(trifluoromethyl)-1H-benzo[d]imidazole 
• 384-32-7 2-methyl-4-(trifluoromethyl)-1H-benzo[d]imidazole 
• 157026-18-1 4-bromo-2-nitro-6-trilfuoromethyl-phenylamine 

24821-17-8Relevant articles and documents

TREATING LONG QT SYNDROME

-

Page/Page column 33, (2020/08/22)

This document relates to compounds useful for treating and preventing disorders associated with long QT syndrome such as cardiac arrhythmia, ventricular arrhythmia, hypertrophic cardiomyopathy, and congestive heart failure. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient.

A convenient copper-catalyzed direct animation of nitroarenes with 9-alkylhydroxylamines

Seko, Shinzo,Miyake, Kunihito,Kavvamura, Norio

, p. 1437 - 1444 (2007/10/03)

O-Alkylhydroxylamines, particularly O-methylhydroxylamine, aminate nitroarenes in the presence of a strong base and a copper catalyst to give aminonitroarenes in good yields, ortho- or para-Animation with respect to the nitro group takes place, and in some cases the ortho-aminated product is preferentially obtained. With 3-substituted nitrobenzenes where the substituent has a lone pair of electrons, preferential amination occurs at the 2-position to give the sterically most congested 3c-f, 14 and 22g.

Direct Nitration of Anilines Using Nitrocyclohexadienones

Lemaire, M.,Guy, A.,Boutin, P.,Guette, J. P.

, p. 761 - 763 (2007/10/02)

Nitrocyclohexadienones (in particular, 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone) are used as reagents for the direct nitration of anilines.Depending on the conditions, good yields of C-nitroanilines are obtained.Under the same conditions, N,N-dimethylaniline is converted into N-methyl-N-nitroaniline.

Quinoxaline derivatives as immune regulants

-

, (2008/06/13)

Novel quinoxaline derivatives, useful as immune regulatory agents capable of altering the immune response in mammals.

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