183742-84-9Relevant articles and documents
Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(ω-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone
Dodean, Rozalia A.,Kelly, Jane X.,Peyton, David,Gard, Gary L.,Riscoe, Michael K.,Winter, Rolf W.
, p. 1174 - 1183 (2008/09/17)
In this study, the effect of fluorine upon the heme-binding ability of the xanthone nucleus was investigated for 3,6-bis-(ω-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone (F2C5). 2-Fluoro-1,3-dimethoxybenzene was prepared by a new, improved method and used to build up the xanthone nucleus. The interaction of F2C5 with heme was investigated by UV-vis, 1H NMR, and 19F NMR spectroscopy. For the first time, NMR studies for the heme-drug interactions are carried out at pH 5.0, physiological for the acidic food vacuole of the malaria parasite.
Elemental fluorine. Part 6. Fluorination of cyclic 1,3-diketones and related compounds
Chambers, Richard D.,Hutchinson, John,Batsanov, Andrei S.,Lehmann, Christian W.,Naumov, Dimitrii Y.
, p. 2271 - 2275 (2007/10/03)
Direct fluorination of cyclic 1,3-diones gives 2-mono- and 2,2-di-fluorinated products. The monofluorinated compounds crystallise in their enol forms and the difluorinated compounds form stable monohydrates whose crystal structures have been elucidated. D
