110811-34-2Relevant articles and documents
Preparation of Tetrahydropyran Derivatives with α-Electron-Withdrawing Substituents from 1,5-Dibromopentane Derivatives by Treatment with Silver Nitrate
Mitani, Michiharu,Takeuchi, Hiroshi,Koyama, Kikuhiko
, p. 333 - 334 (1987)
When 1,5-dibromopentane derivatives having the electron-withdrawing groups at one terminus, wich were obtained by Cu(I)-catalyzed photochemical addition of 1,3-dibromopropanes to electron-deficient olefins, were subjected to treatment with silver nitrate, tetrahydropyran derivatives with the electron-withdrawing groups at the α-position to the oxygen atom were obtained.
Use of a conformational radical clock for evaluating alkyllithium-mediated cyclization reactions
Rychnovsky, Scott D.,Hata, Takeshi,Kim, Angie I.,Buckmelter, Alexandre J.
, p. 807 - 810 (2001)
matrix presented The reductive lithiation of nitrile 9 led to the cyclic product 11 as a single diastereomer in 42% ee. The intermediate radical is a conformational radical clock. The radical lifetime can be determined from the optical purity of the produ
Cyclopropenium-activated cyclodehydration of diols
Kelly, Brendan D.,Lambert, Tristan H.
, p. 740 - 743 (2011/05/04)
The dehydrative cyclization of diols to cyclic ethers via cyclopropenium activation is described. Using 2,3-diphenylcyclopropene and methanesulfonic anhydride, a series of 1,4-and 1,5-diols are rapidly cyclized to furnish tetrahydrofurans and tetrahydropyrans in high yield. Eleven total substrates are shown, including a gram scale cyclization of a diterpene derivative.
ALPHA SUBSTITUTED CARBOXYLIC ACID AS PPAR MODULATORS
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Page 123, (2010/02/09)
Alpha substituted carboxylic acids of formula (I): wherein R' and R2 are as defined in the specification and R3 is A) formula (II); B) formula (III); C) formula (IV); and D) formula (V); wherein Y, Art, Are, AP, R4, R5, R6, R7, R6, R9, R9a, R10, R", R12, R17, ring A, and p are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR, specifically PPAR α/y related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.
Conformational memory in enantioselective radical reductions and a new radical clock reaction
Buckmelter, Alexandre J.,Kim, Angie I.,Rychnovsky, Scott D.
, p. 9386 - 9390 (2007/10/03)
The radical decarboxylation of acid 1 led to tetrahydropyran 3 with significant optical activity. This transfer of chirality is an example of a conformational memory effect and derives from the slow ring inversion of the atropisomer 2 and its enantiomer 2
Optionally substituted phenylimidazolidines, their preparation process and intermediates, their use as medicaments and the pharmaceutical compositions containing them
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, (2008/06/13)
A compound in all possible racemic, enantiomeric and diastereoisomer forms of the formula STR1 wherein Y is --O--, Z 2 is --CF 3, Z 1 is --CN or --NO 2, X is --O-- or --S--, R 3 is hydrogen or alkyl of 1 to 4 carbon atoms optionally substituted by at least one halogen or --CN and R 4 and R 5 are individually alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, --OH, esterified or etherified or protected hydroxy and phenylthio optionally substituted by halogen or --OH, and wherein at least one of R 4 and R 5 is substituted having antiandrogenic activity.
