102308-97-4Relevant articles and documents
Novel anellated pyrazoloquinolin-3-ones: Synthesis and in vitro BZR activity
Ferlin, Maria Grazia,Chiarelotto, Gianfranco,Dall'Acqua, Stefano,MacIocco, Elisabetta,Mascia, Maria Paola,Pisu, Maria Giuseppina,Biggio, Giovanni
, p. 3531 - 3541 (2005)
A series of pyrazolo[4,3-c]pyrrolo[3,2-f]quinolin-3-one derivatives 6, 7a-c, 8a,b, 9a,b and 10-12 were synthesized as modified pyrazoloquinolinone analogs (PQs) and evaluated for their ability to inhibit radioligand to central and peripheral benzodiazepin
3-Substituted 7-phenyl-pyrroloquinolinones show potent cytotoxic activity in human cancer cell lines
Gasparotto, Venusia,Castagliuolo, Ignazio,Ferlin, Maria Grazia
, p. 5509 - 5513 (2007)
A novel series of 3-alkyl-substituted 7-phenyl-3H-pyrrolo[3,2-f]quinolin-9- ones (7-PPyQs) was synthesized with the aim to optimize the cytotoxic activity of recently identified PPyQs, promising inhibitors of tubulin polymerization. All compounds inhibited the growth of 11 human tumor cell lines at submicromolar concentrations as well as two human resistant cancer sublines, A549-T12 and A549-T24. FACS analysis indicated that all compounds caused significant arrest of the A549 cell cycle in G2/M phase at 0.1 and 1 μM and a good correlation between the cytotoxicity IC50 and their ability to block the cell cycle was observed.
Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B
Elkamhawy, Ahmed,Paik, Sora,Kim, Hyeon Jeong,Park, Jong-Hyun,Londhe, Ashwini M.,Lee, Kyeong,Pae, Ae Nim,Park, Ki Duk,Roh, Eun Joo
, p. 1568 - 1580 (2020)
Herein, two new series of N-substituted indole-based analogues were rationally designed, synthesized via microwave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hits VI and VII, compounds 4b and 4e exhibited higher inhibitory activities over MAO-B with IC50 values of 1.65 and 0.78?μM, respectively. When compared to the modest selectivity index of rasagiline (II, a well-known MAO-B inhibitor, SI > 50), both 4b and 4e also showed better selectivity indices (SI > 60 and 120, respectively). A further kinetic evaluation of the most potent derivative (4e) displayed a competitive mode of inhibition (inhibition constant (K i)/MAO-B = 94.52 nM). Reasonable explanations of the elicited biological activities were presented via SAR study and molecular docking simulation. Accordingly, the remarkable MAO-B inhibitory activity of 4e (N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide), with its selectivity and competitive inhibition, advocates its potential role as a promising lead worthy of further optimization.
A general palladium-catalyzed animation of aryl halides with ammonia
Schulz, Thomas,Torborg, Christian,Enthaler, Stephan,Schaeffner, Benjamin,Dumrath, Andreas,Spannenberg, Anke,Neumann, Helfried,Boerner, Armin,Beller, Matthias
, p. 4528 - 4533 (2009)
A study was conducted to demonstrate palladium(Pd)-catalyzed amination of aryl halides with ammonia. The active catalyst was formed in situ from Pd(OAc)2, along with air- and moisture stable phosphines as pre-catalysts. It was found that the productivity of the catalyst system was similar to that of competitive Pd and phosphine systems. It was demonstrated that the novel electron-rich sterically demanding phosphine ligand was unable to be displaced from the palladium by ammonia to a significant extent, which prevented the deactivation of the catalyst by the ligand. It was also demonstrated that the Pd-catalyzed animation worked at ambient pressure. It was observed that the optimized system showed an excellent substrate scope including deactivated, electron-neutral, and activated halides, o-, m- p-substituted substrates, aryl chlorides, and heterocycles.
Chemoselective transfer hydrogenation of nitroarenes by highly dispersed Ni-Co BMNPs
Zhang, Jia-Wei,Lu, Guo-Ping,Cai, Chun
, p. 25 - 29 (2016)
Highly dispread Ni-Co bimetallic nanoparticles (Ni-Co BMNPs) are synthesized and applied as an efficient catalyst in the chemoselective transfer hydrogenation of nitroarenes (CTH) using hydrazine hydrate as the hydrogen donor. The BMNPs can efficiently catalyze the reduction reaction without any additives under mild conditions with high TOF. Significantly higher activity is achieved when compared with corresponding single-component catalysts, optimal composition of the Ni-Co BMNPs was screened which was proved to be crucial in both the selectivity and yields. Excellent performance of Ni-Co BMNPs can be ascribed to the improved dispersion of active sites on the BMNPs surface (compared with Ni NPs) and the electron transfer from cobalt to nickel.
Electroreduction of 1-methyl 5-nitroindole, 5-nitrobenzofurane, and 5-nitrobenzothiophene in acidic and basic hydroorganic media: Generation and trapping of iminoquinone-type intermediates and electrosynthesis of ring-substituted amino derivatives
Bouchard, Luc,Marcotte, Ian,Chapuzet, Jean Marc,Lessard, Jean
, p. 1108 - 1118 (2003)
Preparative electrolysis of 1-methyl-5-nitroindole (1b, X = NCH 3), 5-nitrobenzofurane (1c, X = O), and 5-nitrobenzothiophene (1d, X = S) at Hg, in acidic hydromethanolic media, leads to the formation of the corresponding 4-substituted amino derivatives 5, which result from the 100% regioselective addition to iminoquinone-type intermediate 4 of methanol or of any other good nucleophile present in the electrolytic solution. In acidic medium, the iminoquinonium intermediates 4b and 4c were trapped in a cycloaddition reaction with cyclopentadiene added to the electrolysis medium. The regiochemistry of the nucleophilic addition is discussed in light of AM1 calculations.
Direct C-H bond arylation: Selective palladium-catalyzed C2-arylation of N-substituted indoles
Lane, Benjamin S.,Sames, Dalibor
, p. 2897 - 2900 (2004)
(Equation Presented) We present a new, practical method by which N-substituted indoles may be selectively arylated in the C2-position with good yields, low catalyst loadings, and a high degree of functional group tolerance. Our investigation found that two competitive processes, namely, the desired cross-coupling and biphenyl formation, were operative in this reaction. A simple kinetic model was formulated that proved to be instructive and provided useful guidelines for reaction optimization; the approach described within may prove to be useful in other catalytic cross-coupling processes.
Iridium-catalyzed transfer hydrogenation of nitroarenes to anilines
Chen, Shujie,Lu, Guoping,Cai, Chun
, p. 5360 - 5365 (2015)
A simple and general homogeneous catalyst system composed of commercially available [Ir(cod)Cl]2 and 1,10-phenanthroline has been developed for the selective transfer hydrogenation of nitroarenes to anilines. It utilized the readily accessible 2-propanol as a hydrogen donor and had wide substrate scope. A careful mechanistic investigation through real-time detection and a series of controlled experiments with possible intermediates was also carried out, which showed that the transformation proceeds via both phenylhydroxylamine and azobenzene intermediates and the reduction of hydrazobenzene leading to aniline might be the rate-determining step.
Synthesis and in Vitro Evaluation of Novel 5-Nitroindole Derivatives as c-Myc G-Quadruplex Binders with Anticancer Activity
Nimbarte, Vijaykumar D.,Wirmer-Bartoschek, Julia,Gande, Santosh L.,Alshamleh, Islam,Seibert, Marcel,Nasiri, Hamid Reza,Schnütgen, Frank,Serve, Hubert,Schwalbe, Harald
, p. 1667 - 1679 (2021/03/24)
Lead-optimization strategies for compounds targeting c-Myc G-quadruplex (G4) DNA are being pursued to develop anticancer drugs. Here, we investigate the structure-activity- relationship (SAR) of a newly synthesized series of molecules based on the pyrrolidine-substituted 5-nitro indole scaffold to target G4 DNA. Our synthesized series allows modulation of flexible elements with a structurally preserved scaffold. Biological and biophysical analyses illustrate that substituted 5-nitroindole scaffolds bind to the c-Myc promoter G-quadruplex. These compounds downregulate c-Myc expression and induce cell-cycle arrest in the sub-G1/G1 phase in cancer cells. They further increase the concentration of intracellular reactive oxygen species. NMR spectra show that three of the newly synthesized compounds interact with the terminal G-quartets (5′- and 3′-ends) in a 2 : 1 stoichiometry.
Novel heteroaryl amide derivatives as MAO-B inhibitors and pharmaceutical compositions for preventing, ameliorating or treating neurodegenerative diseases comprising the same
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, (2021/04/06)
A novel heteroaryl amide derivative compound useful as MAO-B inhibitors. The present invention relates to a compound selected from a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, and a pharmaceutical composition comprising the compound as an active ingredient for preventing, alleviating, or treating neurodegenerative diseases such MAO as B's disease, 's disease, 's disease, and the like.
